Università Cattolica del Sacro Cuore

Protein Folding in the Cell: At the Intersection of Physics, Chemistry & Biology

Lezione  dal 29 giugno 2017 al 30 giugno 2017
Aula: Aula 2 -  Via Musei 41, Brescia


Prof.ssa Patricia L. CLARK
Department of Chemistry & Biochemistry, University of Notre Dame, USA

Giovedì 29 giugno
dalle ore 10.00 alle ore 13.00 e dalle ore 14.00 alle ore 16.00

Venerdì 30 giugno
dalle ore 10.00 alle ore 13.00

Proteins are linear polymers that must fold into specific three-dimensional structures in order to perform their biological function. The failure of proteins to fold correctly is the cause of diverse human diseases, including Alzheimer’s, cystic fibrosis, juvenile cataracts and many forms of cancer. These seminars will discuss current projects to understand the extent of polypeptide chain collapse in water, the features of native protein structures that can lead to protein misfolding and aggregation, and mechanisms for vectorial folding during protein synthesis and secretion across a lipid membrane. A specific focus is the folding of large, complex protein structures, as these tend to be most prone to misfolding and aggregation.

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